Arsenal travel to Old Trafford to take on a Manchester United side high on confidence after picking wins in their first two games of the new Premier League season.
United have won plaudits for their attacking style so far this season, and were rampant as they defeated Tottenham Hotspur 3-0 on Monday.
Arsenal meanwhile have endured a torrid start to their season and are yet to record a victory after drawing with Newcastle and losing at the Emirates to Liverpool last week.
A week that begun badly for Arsenal boss Arsene Wenger as key midfielder Samir Nasri departed for Manchester City ended well as the Gunners recorded a crucial victory over Udinese that put them into the group stages of the Champions League for the 14th season running, and Wenger will be hoping to take the momentum from that game into the showdown with their fierce rivals.
Arsenal will be without new striker Gervinho and midfielder Alex Song who were both handed three week bans for their part in the fracas against Newcastle which saw the Ivorian sent off and Song cited for stamping on Joey Barton.
Jack Wilshere will also be absent from Arsenal’s midfield as he continues to suffer the effects of a long term ankle problem.
United meanwhile will be without captain Rio Ferdinand who is still recovering from injury, but with the likes of Phil Jones and Chris Smalling on hand as cover, manager Sir Alex Ferguson will be more than happy with his defensive options going into the game.
The home side are favourites for the game and are best priced at 5/11 and should add to the Gunners woes while Arsenal are 11/2 to emerge with all three points.
Robin Van Persie ended last season in spectacular goal scoring form, finding the net in his last ten games, and bagged another against Udinese on Wednesday. The Dutchman is good value to open the scoring at 17/2, while Theo Walcott has found his goal scoring boots of late and may be worth a punt at 14/1.