Wales ran out 1-0 winners as Gareth Bale scored to push the Welsh within a whisker of Euro 2016 qualification.
The Red Devils have reached their highest ever world position, amazingly climbing from 71 to 2 in just 8 years.
The Belgians, under the guidance of Marc Wimots, were tipped to make an impression at the world cup last year and while they were eventually undone by Argentina, a run of seven games unbeaten has seen them usurp the world cup runners-up.
Wales v Belgium Live from 19:45
Wilmots currently top the group but only on goal difference ahead of the Welsh and according to defender Toby Alderweireld both sides are capable of reaching the finals in France.
“They have the quality to qualify, but we want to go through in first place,” Alderweireld said.
“It’s going to be difficult, they have good players and we are both first in the group.”
If Wales are to qualify for the first major tournament since 1958 they will need Gareth Bale to be at his best.
While Belgium were busy beating France 4-3, Bale and his Wales team-mates prepared for the qualifier with a five-day training camp.
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The Real Madrid forward has endured a frustrating second half of the season at club level but he is set to be the main man for Chris Coleman this weekend.
Coleman is expected to play Bale in a more central attacking role as a lone forward as he looks to take advantage of the absence of Vincent Kompany.
Manchester City captain Kompany is suspended following his red card against Israel.
However while Kompany will be missing, Belgium will have Bundesliga Player of the Year Kevin de Bruyne available.
The former Chelsea midfielder has shaken off an ankle problem and will join Alex Witsel, Marouane Fellaini and Radja Nainggolan in a very physical and imposing midfield.