England will see this as a great chance to move on and turn their attention to the One Day format of the game as the two sides go head-to-head again in Cardiff on Friday.
Alistair Cook will now take charge of the side from Andrew Strauss, who of course does not play in limited overs cricket.
Cook will be hoping that his team can show the type of form that saw them demolish Australia 4-0 in the ODI series earlier in the summer.
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There will be a change around in personal for the 50-over game. Stuart Broad is being rested for the series and the likes of Eoin Morgan, Samit Patel, Craig Kieswetter and Chris Woakes all come into the squad.
England will be desperate to return to winning ways and re-install some confidence in the team as it is sure to be low after the Test series defeat.
The Three Lions certainly have shown that they are a good One Day outfit over the last year or so and they will not want to let their form slip.
As for South Africa, it is all about using their momentum to keep winning matches. The squad is sure to be in fantastic spirits after securing the number one in the world spot in Test matches.
Now though, they will be targeting One Day success and with the players they have at their disposal, will certainly be a force to be reckoned with.
With big hitters that go a long way down the order, a bowling attack that has proved itself as the best in the world and fielders who cling on to catches – the Proteas have a great balance in their side.
The tourists will be targeting a victory in Cardiff to take the early initiative and dent England’s confidence in this five match series.