Both teams will be determined to get their first Premier League points of the season on the board.
On the same day Southampton were pushing Manchester City all the way at the Etihad Stadium, before losing 3-2, Wigan were defeated at home to a slick Chelsea side inspired by Eden Hazard.
It was therefore a tough start for both teams and this weekend perhaps presents them with their first realistic chance of registering a victory.
Focusing on Southampton to begin with, they will have taken a lot of heart from their performance at Manchester City. They showed no fear and took the positivity from back to back promotions into the top flight.
The next step is winning games of course, especially on home soil against teams that could be in and around them come the end of the campaign. Nigel Adkins men had nothing to lose last weekend, but the pressure is on for this one – defeat would be hugely disappointing.
Wigan were strong on the road at the back end of last season though, so they will be keen to continue this on Saturday afternoon.
You never quite know what to expect from Roberto Martinez’s men of course. If they show their early season form from last year – they could be hammered. If they show the form that kept them up from March onwards, they could look like a well organised, counter attacking outfit.
The Latics fans will certainly hope it is the latter and that this is the game you can read into with regards to their hopes for the season, not the opening defeat to a very good Chelsea side.
You would expect Southampton – backed by a crowd delighted to be back in the big time – to start at a very high tempo, but Wigan will look to weather the storm and take their chances when they come.
This fascinating contest, which could be crucial come the end of the season, gets underway at 3pm on Saturday.