The British No.1 has had a whirlwind few weeks of course, losing in the Wimbledon final before securing the gold medal at the London 2012 Olympics.
It has already been the most successful year of his career, one where he has won even more fans and it would be an incredible achievement if he manages to put his emotions of the last month or so aside and secured the title at Flushing Meadows.
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As ever with these type of tournaments, he is going to have to beat the big guns to succeed. Novak Djokovic is the defending Champion and will be determined to retain his title, while Roger Federer is in some of the best form of his life.
Focusing on Djokovic for a second, there is no doubt that the defeat at Wimbledon would have hurt. It was his title and he lost it. The Serb is far too competitive to want this to happen again. He will be incredibly focused on one thing and one thing only – winning the US Open.
As for Federer, he hasn’t won this particular Grand Slam since 2008, so victory would mean a great deal. In 2012, he has already won Wimbledon and moved to No.1 in the world, so add a US Open title and even for Federer, this year will go down as one of the best.
These three are certainly the front runners with Djokovic and Federer likely to receive the biggest threat from Murray. You then have Juan Martin Del Potro, winner of this tournament in 2009, that many people hope finds his best form.
Jo Wilfried Tsonga is always a dangerous opponent to with his big serve and powerful stroke play. The Frenchman is a popular figure with the crowd too, something he soaks up during the matches.
Speaking of the crowd, their biggest hope of a home victory is John Isner. Mardy Fish and Andy Roddick are then slightly further adrift. You then have Spain’s David Ferrer – who has been in top form this year – likely to be in the mix for the last eight at least.
Overall, a cracking tournament awaits from the moment of the first serve on Monday.