The Saints are proving a popular selection as the latest Southampton v Tottenham odds see the home side an attractive 8/5 to take advantage of the continued woes of Spurs (KO 13:30 GMT).
Managerless Tottenham will look to bounce back from successive defeats when they travel to take on Southampton, with the side still reeling from the dismissal of Andre Villas-Boas and a successor yet to be announced by the London club.
William Hill reported this morning that plenty of their customers are backing the home side, with Spurs looking a little brittle going forward at the moment.
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It should be an intriguing tie, as both sides have been inconsistent of late and will hope to avoid losing further ground on the chasing pack with the busy festive schedule kicking in.
Despite their very recent poor form, Spurs have a good record against Southampton winning three of the last four meetings between the clubs, including both games last season.
The Saints however are a very different proposition this season and have already taken points of Liverpool, Manchester United and Manchester City this season.
The club are currently 9th in the table but without a win in their last five league wins. Spurs meanwhile had been on a five game unbeaten run before their capitulation against Liverpool.
That result cost Andre Villas-Boas his job and Tim Sherwood, the interim manager, began his rein with a home defeat to West Ham in the Capital One Cup Quarter-final.
Despite the recent upheaval at a managerial level, the Londoners are still very much in the hunt for the title lying 8 points off the leaders Arsenal in 7th place.
Spurs will be missing a number of key men with Paulinho suspended following his red card against the Reds while Andros Townsend, Jan Vertonghen and Younes Kaboul are all out injured.
The Saints meanwhile will once again be without first choice keeper Artur Boruc and his deputy Kelvin Davis with Paulo Gazzaniga set to once again deputise.
Midfielder Victor Wanyama is still recovering from a calf problem and won’t be seen again in a Southampton shirt until early 2014 while Nathaniel Clyne and Danny Fox are struggling with hamstring problems and are rated as doubtful for the game.
Dani Osvaldo is set to play despite being charged by the FA for the touchline fracas that marred the draw with Newcastle last time out. The former Roma striker, with 2 goals to his name in December, has until Monday to respond and could face up to a three game ban.
The Italian is clear to play this weekend and will hope to fire Southampton to a win that would see them overtake Spurs on goal difference.